Non-solid oncogenes in solid tumors:EML4-ALKfusion genes in lung cancer
نویسندگان
چکیده
منابع مشابه
Oncogenes and onco-suppressor genes in lung cancer.
Prognosis in lung cancer, one of the commonest cancers in the developed world, is poor, with less than 13% of all lung cancer patients surviving more than 5 years after diagnosis. With such an elevated mortality rate, it is important to elucidate the genetic changes involved in the pathogenesis of lung cancer. The process of carcinogenesis can be divided into the three stages of initiation, pro...
متن کاملMutation-associated fusion cancer genes in solid tumors.
Chromosomal translocations and fusion oncogenes serve as the ultimate biomarker for clinicians as they show specificity for distinct histopathologic malignancies while simultaneously encoding an etiologic mutation and a therapeutic target. Previously considered a minor mutational event in epithelial solid tumors, new methodologies that do not rely on the detection of macroscopic cytogenetic alt...
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BACKGROUND Recent studies have demonstrated that sublobar resection is not inferior to lobectomy for peripheral early lung cancer with ground-glass opacification. However, the effect of sublobar resection on solid-type early lung cancer is controversial. The aim of this study was to compare clinical outcomes of patients who have undergone sublobar resection or lobectomy for solid-type, early-st...
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Small cell lung cancer (SCLC) makes up almost 15% of all cases of lung cancer and occurs almost exclusively in individuals with a history of smoking (Blackhall & Faivre-Finn, 2011; Meyerson et al., 2004; Tamasi and Muller, 2011; Walenkamp et al., 2009). However, SCLCs differ significantly from NSCLCs in specific genetic alterations that occur. Moreover, smoking-damaged bronchial epithelia accom...
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Introduction Pulmonary nodules present a unique challenge for radiologists which includes the detection of malignancy and identification of benign disease, recommending the appropriate procedures to avoid unnecessary thoracotomy, and ensuring that excessive radiation from follow-up computed tomography (CT) examinations is kept to a minimum. Although seasoned radiologists can use an approach bas...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2008
ISSN: 1347-9032,1349-7006
DOI: 10.1111/j.1349-7006.2008.00972.x